SEPN logo

SEPTERNA INC

SEPNNASDAQ
πŸ† #1558 by market capEarnings Nov 9US Equity
$47.71β–² $10.94 (+22.93%)
Live
1hβ€”
24hβ–² 22.9%
7dβ–² 22.2%
14dβ–² 40.2%
30dβ–² 32.9%
1yβ–² 314.3%
🏦Market Cap
$2.15B
Small Cap
πŸ“ˆRevenue Growth (YoY)
+11790.1%
High Growth
πŸ“ŠGross Margin
β€”
πŸ’΅FCF Margin
β€”
βš–οΈP/S Ratio
24.2x
Expensive
Otter Score
61
Fair

Trading Snapshot

Day Range
$47.29 – $48.06
52-Week Range
$10.62 – $40.65
Volume
$2.80B
Avg Volume
$2.73B
Shares Outstanding
45.1M
Next Earnings
Oct 19, 2026

Fundamentals Snapshot

Annual Revenue
$72M
Last Q Revenue
$17M
P/E Ratio
β€”
P/S Ratio
24.2x
EPS (TTM)
$-0.82
Dividend Yield
β€”

Why Investors Own SEPN

  • βœ“High-growth profile β€” revenue up +42.7% YoY with expanding US Equity exposure.
  • βœ“Healthy economics β€” 37% gross margin and 15% free-cash-flow margin.
  • βœ“New products and segments could unlock additional revenue streams.
⚠️ Key Risks

Execution delays, intensifying competition, and valuation compression if growth decelerates.

Financial Trends

Revenue (TTM)
$72Mβ–² +43.9% YoY
Gross Margin (TTM)
37.4%β–² +3.9% YoY
Operating Income (TTM)
$20Mβ–² +43.9% YoY
Free Cash Flow (TTM)
$11Mβ–² +43.9% YoY

About SEPTERNA INC

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

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Otter Score Breakdown

β“˜
πŸ’ŽQualityβ˜…β˜…β˜…β˜…β˜…
πŸš€Growthβ˜…β˜…β˜…β˜…β˜…
βš–οΈValuationβ˜…β˜…β˜…β˜…β˜…
⚑Momentumβ˜…β˜…β˜…β˜…β˜…
Overall Score
Fair
61/100

Analyst Ratings

β“˜
Consensus
Buy
16 analysts
Strong Buy5
Buy10
Hold1
Sell0
Strong Sell0
Ratings as of Aug 2026

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