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SEPTERNA INC

SEPNNASDAQ
πŸ† #1885 by market capEarnings Nov 25US Equity
$44.25β–² $0.11 (+0.25%)
πŸŒ… Pre-market$44.04β–Ό 0.48%Regular close Β· extended-hours price shown
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24hβ–² 0.3%
7dβ–² 8.4%
14dβ–² 18.1%
30dβ–² 13.0%
ytdβ–² 59.4%
1yβ–² 101.8%
🏦Market Cap
$2.07B
Small Cap
πŸ“ˆRevenue Growth (YoY)
4174.5%
High Growth
πŸ“ŠGross Margin
99.6%
High
πŸ’΅FCF Margin
106.3%
Strong
βš–οΈP/S Ratio
20.8x
Expensive
Otter Score
56
Fair

Trading Snapshot

Day Range
$42.40 – $45.05
52-Week Range
$17.55 – $51.10
Volume (shares)
380,134
Avg Volume (shares)
β€”
Shares Outstanding
46.7M
Next Earnings
2026-11-25

Fundamentals Snapshot

Annual Revenue
$46M
Last Q Revenue
$27M
P/E Ratio
-81.7
P/S Ratio
20.8x
EPS (TTM)
$-0.54
Dividend Yield
0.00%
Dilution (1yr)
+36.7%
SEPN logo

SEPTERNA INC

SEPN
Financial Trends
RevenueThe total money the company brought in from sales, before subtracting any costs.
$46Mβ–² +4174.5% YoY
Gross MarginOf every $1 of sales, how much is left after the direct cost of making the product/service. Higher = more efficient.
100.0%β–² +0.0% YoY
Operating IncomeProfit from the core business after operating costs, but before interest and taxes. Negative means the core business isn’t profitable yet.
βˆ’$81Mβ–² +0.0% YoY
Free Cash FlowCash left over after running the business and paying for equipment/capex. Negative means the company is burning cash.
$110Mβ–Ό βˆ’257.6% YoY
Shares OutstandingHow many shares exist. Rising means the company is issuing more shares, which dilutes (shrinks) each existing owner’s slice.
44.3Mβ–² +36.7% YoY
Net CashCash minus total debt. Positive = more cash than debt (financially strong); negative = more debt than cash (net debt).
$97Mβ–Ό βˆ’$116M YoY
StockOtter Β· stockotter.space

About SEPTERNA INC

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

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Otter Score Breakdown

How it's scoredFive components, each rated 1–5β˜… and equally weighted (20%), averaged to a 0–100 score:πŸ’Ž Quality β€” gross marginπŸš€ Growth β€” revenue YoYβš–οΈ Valuation β€” P/S ratio⚑ Momentum β€” 30-day price changeπŸ’§ Dilution β€” 1-yr share issuance (buybacks score higher)
πŸ’ŽQualityβ˜…β˜…β˜…β˜…β˜…
πŸš€Growthβ˜…β˜…β˜…β˜…β˜…
βš–οΈValuationβ˜…β˜…β˜…β˜…β˜…
⚑Momentumβ˜…β˜…β˜…β˜…β˜…
πŸ’§Dilutionβ˜…β˜…β˜…β˜…β˜…
Overall Score
Fair
56/100

Analyst Ratings

β“˜
Consensus
Buy
16 analysts
Strong Buy5
Buy10
Hold1
Sell0
Strong Sell0
Ratings as of Oct 2026

Latest News & Updates

Defense WorldΒ·9d ago

Septerna (NASDAQ:SEPN) COO Elizabeth Bhatt Sells 4,000 Shares of Stock

Septerna, Inc. (NASDAQ: SEPN - Get Free Report) COO Elizabeth Bhatt sold 4,000 shares of the company's stock in a transaction dated Thursday, October 15th. The shares were sold at an average price of $37.41, for a total

Defense WorldΒ·Sep 28

CRISPR Therapeutics (NASDAQ:CRSP) & Septerna (NASDAQ:SEPN) Head-To-Head Survey

Septerna (NASDAQ: SEPN - Get Free Report) and CRISPR Therapeutics (NASDAQ: CRSP - Get Free Report) are both healthcare companies, but which is the better stock? We will compare the two companies based on the strength of

Defense WorldΒ·Sep 24

Analyzing Valneva (NASDAQ:VALN) and Septerna (NASDAQ:SEPN)

Valneva (NASDAQ: VALN - Get Free Report) and Septerna (NASDAQ: SEPN - Get Free Report) are both small-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of t

Defense WorldΒ·Sep 22

Comparing WAVE Life Sciences (NASDAQ:WVE) and Septerna (NASDAQ:SEPN)

Septerna (NASDAQ: SEPN - Get Free Report) and WAVE Life Sciences (NASDAQ: WVE - Get Free Report) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on

Defense WorldΒ·Sep 16

VIRGINIA RETIREMENT SYSTEMS ET Al Buys Shares of 13,300 Septerna, Inc. $SEPN

VIRGINIA RETIREMENT SYSTEMS ET Al purchased a new stake in shares of Septerna, Inc. (NASDAQ: SEPN) during the undefined quarter, according to its most recent Form 13F filing with the Securities and Exchange Commission. T

GlobeNewsWireΒ·Sep 10

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

SOUTH SAN FRANCISCO, Calif., Sept. 10, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), today announced that the Company granted a non-qualified stock option to purchase up to 275,000 shares of the Company's commo